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Clinical efficacy data is from FDA-approved branded GLP-1 medications (Mounjaro, Zepbound, Wegovy, Ozempic)

TB-500 has a longer duration of action affecting cellular migration

More broadly, limited modification strategies and intrinsic nanomaterial properties may contribute to resistance over timefor example, antimicrobial nanomaterials could potentially promote microbial adaptation [145]

In addition, natural compounds can increase the level of nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that regulates the expression of antioxidant and cytoprotective genes through the antioxidant response element (ARE), where their levels are decreased in PD (Aguiar et al