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This combination was associated with higher rates of GI adverse effects and mild hypoglycemia

In animal and in-vitro models, published BPC-157 research has examined areas including: Tendon, ligament, and muscle repair models Gastrointestinal and gut-lining protection models Angiogenesis and microvascular response Interaction with growth-factor and nitric-oxide signaling These are research observations, not established human outcomes

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Earlier studies showed that combining VEGFR and PDGFR inhibitors targeting endothelial cells and pericytes, respectively, improved the efficacy of anti-angiogenic therapy and reduced tumor growth in animal tumor models (Zonneville et al., 2018)