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They work by increasing the release of insulin the hormone that controls blood glucose by moving it into cells and suppressing the release of glucagon, which releases glucose from the liver into the blood

Why Long-Term Risks Are Still Uncertain GLP-1 drugs are relatively new, and large-scale studies have primarily focused on: 612 month use diabetes-specific outcomes cardiovascular risk reduction What we dont have yet: long-term (515 year) safety data long-term pancreatic outcome studies long-term GI motility tracking full population data on chronic or permanent side effects long-term cancer risk data Large numbers of patients now take GLP-1 drugs indefinitely , especially for weight loss

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