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PMID: 41319798): The study showed phase 1b of 18.8% placebo adjusted weight loss at 24 weeks Phase 2 Trial of CT-388 in Adults with Obesity , published in Roche press release / conference presentation (Roche/Genentech investigators, 2026): The study demonstrated placebo adjusted weight loss of 22.5% at 24 mg dose at 48 weeks The study demonstrated reduced BMI below obesity threshold of 54% vs 13% placebo The study showed discontinuation due to AEs of 5.9% vs 1.3% CT-388 research studies and evidence CT-388 dosing protocols CT-388 side effects profile Tirzepatide research guide Semaglutide research guide

Whilst no direct causal link has been established by regulatory bodies, understanding the theoretical mechanisms, recognising symptoms, and implementing protective strategies remain essential components of safe treatment

In this article, we explain what GLP-1 drugs are, the different types available and how effective they are, along with how to support your body while taking them

The first four weeks are adaptation