Numerous classes of medication used to treat nausea, including 5-HT 3 antagonists, phenothiazines, cannabinoids and H1 receptor antagonists such as diphenhydramine, have not been evaluated adequately in the context of diabetic gastroparesis but may have a place in its management [3]
In the agent-level analysis, tirzepatide demonstrated comparable efficacy to the majority of individual GLP-1RAs across outcomes
Given that FOXO4-DRI remains in the preclinical arena (i.e., animal models, in-vitro cell culture), lets review key studies and what they suggest
A particularly concerning condition associated with these drugs is stomach paralysis, or gastroparesis, a chronic condition where the stomach takes longer to empty its contents and potentially leads to blockages, resulting in significant discomfort and potentially severe complications