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For some substances, it is important to think of the human or animal body as being made up of several parts, each with its own affinity for the substance, and each part with a different biological half-life (physiologically-based pharmacokinetic modelling)

Theres also some inflammation thats being generated in that stress state, and it seems as though creatine is also having both an indirect and direct effect on inflammatory processes as well

However, safety varies significantly based on individual factors including age, liver and kidney function, concurrent medications, and underlying genetic polymorphisms affecting antioxidant metabolism