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Description

At the pathophysiological level, it is now clear that most narcolepsy cases with cataplexy, and a minority of cases (530 %) without cataplexy or with atypical cataplexy-like symptoms, are caused by a lack of hypocretin (orexin) of likely an autoimmune origin

6k and Supplementary Fig

The standard protocol is 4 weeks on, 2 to 4 weeks off

Purified recombinant protein (3 g) was resolved using 18% w/v SDS-PAGE in reduced (+-mercaptothanol, R) and non-reduced (NR) conditions and stained with Coomassie Brilliant Blue R250