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This could be explained by the fact that levels of calcidiol, an intermediate metabolite generated in the liver from calcifediol, have been correlated with high levels of insulin-like growth factor 1 (184), which activates the mitogen-activated protein kinase and phosphoinositide 3-kinase pathways, and promotes cell proliferation in PCa (183, 185)

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Because of the additional interaction of linagliptin with S2 subsite, it has an eightfold higher activity than alogliptin

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