Some reports have demonstrated that more than 50% of patients with depression experience chronic and recurrent problems throughout their lifetime, and that depressive symptoms can gradually aggravate and lead to suicide if patients are not treated with proper drugs or counseling (Monroe and Harkness, 2005
and Instituto de Investigacin e Innovacin Biomdica de Cdiz (INiBICA), Cdiz, Spain 12-Deoxyphorbols (1-3) from Euphorbia resinifera have been described by our research group as non-tumorogenic promoters of neural progenitor cells (NPCs) expansion.[1] The activity of this class of compounds is correlated with the modulation of protein kinase C (PKC).[1] Phorbol esters modulation of PKCs involves binding with C1 protein domain and translocation of the complex to membrane, through hydrogen bond interactions of oxygenated funcional groups at C-3, C-4 and C-20 on phorbol derivatives, with specific protein residues.[2] Translocation of the complex phorbol/PKC within the cell depends of the nature of esters chains, for instance, at C-12 and C-13,[3] and this, on the other hand, has an influence on the nature of the biological activity
En la dieta acompaada de termognicos, lo ms importante es disminuir el consumo de carbohidratos de alto ndice glucmico (no TODOS los carbohidratos)
Medium chain fatty acids (sodium caprylate C 8 , sodium caprate, C 10 ) and derivatives (the Eligen candidate, salcaprozate sodium (SNAC)) along with EDTA, bile salts, and acyl carnitines are the main examples of enhancers
