The liver relies heavily on glutathione to facilitate the elimination of toxins, drugs, and metabolic waste products
high-dose riboflavin (10 mg kg 1 day 1 ) or flavin esters rapidly restore ATP production and cell viability in vitro ( SLC52A3 knock-down and SLC52A3 / mice recapitulate hearing loss, ataxia and early death, all of which improve with systemic riboflavin supplementation ( SLC52A2 gene replacement normalized FMN/FAD levels, rescued spinal motor neurons and reversed motor deficits when delivered pre-symptomatically, underscoring the feasibility of curative therapy ( Clinically, oral or intravenous riboflavin remains first-line treatment
Although vitamin K has a low potential for toxicity, it can interact with certain medications, such as warfarin and antibiotics ( SUMMARY Both water- and fat-soluble vitamins can cause side effects when taken in high doses, with some causing more severe symptoms than others
If you feel a little nervous about getting the math perfect, you are certainly not alone