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Topical application and microneedling enhance delivery research like the 2025 Kuceki study shows that combining GHK-Cu with microneedling (which creates micro-channels in the scalp) dramatically improves delivery to the target cells and produces measurable regrowth

A clinical trial in aceruloplasminemia (both liver and brain iron overload) showed DFX effectively normalized hepatic iron but had no effect on brain iron levels, indicating the limited CNS distribution of oral DFX (Finkenstedt et al., 2010)