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Phase 1 initiated December 2024, Phase 2 (NCT07101783) initiated October 2025

1 Introduction Atherosclerosis is a chronic metabolic and inflammatory disorder marked by endothelial dysfunction, lipid oxidation, immune cell recruitment, and plaque formation ( Table 1 Summary of the effects of GLP-1 receptor agonists (GLP-1RA) on discussed biomarkers

View Source LANCET DIABETES & ENDOCRINOLOGY Effects of retatrutide on body composition in people with type 2 diabetes 2025 Coskun T, et al

Cardiovascular and kidney outcomes Tirzepatide has cardiovascular outcome data from the SURPASS-CVOT study, which showed favorable effects on major adverse cardiovascular events in people with type 2 diabetes