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Notably, alterations in cholinergic signaling, neuroinflammation involving microglial activation, and calcium dysregulation have emerged as relevant contributors to AD pathogenesis

Sitagliptin, a DPP-4 inhibitor, enhances early insulin secretion by reducing incretin and GLP-1 degradation, reduces peak glucose after oral glucose intake in overweight women with PCOS, and improves visceral obesity [169]

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