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However, the FDA declared the semaglutide shortage resolved in February 2025, and compounded versions are no longer legally available as of May 2025

IGF-1 decreased miR-143 expression and increased IGF1R expression in PC-3 and DU145 cells, and made these cell lines more resistant to docetaxel treatment, suggesting that IGF-1 levels are also involved in resistance to treatment in PCa (54)

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