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SKU: 700191947
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Rather, age-related premutational lesions may have occurred in these cells that are converted to the authentic mutation (most commonly a glycine to arginine substitution at codon 1,138) following fertilization, as a consequence of aberrant DNA repair in the zygote [5, 6]

The prevalence of pruritus varies depending on the underlying cause, with reports indicating rates of up to 70% in primary biliary cholangitis, 2.530% in chronic hepatitis C virus-related liver disease, and roughly 8% in cirrhosis attributed to hepatitis B virus infection (20)