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Inclusion criteria: Diagnosed with type 2 diabetes and 50 years of age and established CVD or CKD OR 60 years of age with at least 1 CV risk factor a Primary composite outcome Time from randomization to first occurrence of MACE: ASCVD=atherosclerotic cardiovascular disease

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These conditions include metabolic syndrome [11, 12], diabetes [4], high blood pressure, atherosclerosis [13], ischemia-reperfusion injury [13], cancer [14, 15], and various neurodegenerative disorders [16]