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Genetics, blood pressure, cholesterol, diabetes, smoking, kidney function, age, and lifestyle remain major determinants of cardiovascular risk

This review integrates current evidence on how brain peptides contribute to AD pathophysiology, summarizes recent progress in peptide-based therapeutic strategies and delivery platforms, and critically examines the remaining barriers to clinical translation, including bloodbrain barrier penetration, metabolic stability, off-target effects, and the need for biomarker-guided patient stratification

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(More information) Supplementation with lipoic acid transiently increases plasma and cellular concentrations of unbound lipoic acid