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Currently, intense media attention and influencer promotion, coupled with robust marketing tactics, have led to an increase in the demand for GLP-1 RAs, resulting in global shortages of these medications

In a Phase 1b trial conducted in China, participants receiving the highest dose of UBT251 demonstrated an average weight loss of 15.1% over 12 weeks, while the placebo group gained 1.5%

A second Phase 3 trial, TRANSCEND-T2D-1 (type 2 diabetes population), showed dramatically lower rates: 4.4% at 12 mg

The two-domain binding mode suggests that the C-terminus of the peptide hormone initiates recognition with the ECD