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However, proposed mechanisms include disruption of microtubule function, potential impact on inflammation in the brain, interference with mitochondrial function, contribution to oxidative stress, and possible disruption of the blood-brain barrier

Blood pressure medications might also need adjustment as weight loss progresses

Based on FDA guidance and current clinical recommendations, the following groups should avoid or exercise extreme caution with GLP-1 receptor agonist peptides: Pregnant or planning pregnancy The FDA recommends discontinuing semaglutide at least two months before a planned pregnancy