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Under stimulation by lipopolysaccharide (LPS) and interferon- (IFN-), macrophages adopt the M1 phenotype ( 3 Macrophage metabolic states and tumor function Macrophage polarization is tightly governed by distinct metabolic programs that determine their effector functions within the tumor microenvironment ( 3.1 Oncogenic functions of tumor-associated macrophages Tumor-associated macrophages (TAMs) represent macrophages recruited and reprogrammed by the tumor microenvironment (TME), exhibiting distinct functional differences from conventional immune macrophages
10.1165/rcmb.2023-0038OC 37 YanqingL.ZhangC.ChengH.LvL.ZhuX.MaM.et al (2024)
Conclusion Riboflavin is a potential neuroprotective agent
Yet, more research is needed to evaluate and confirm the safety and effectiveness of such dosing regimes
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