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main purpose Receptor binding and activation of signaling pathways IGF-1 LR3 activates two main downstream signaling pathways by binding to the IGF-1 receptor (IGF-1R): PI3K/Akt pathway: promotes cell survival, glucose metabolism, and protein synthesis

Cellular fluorescence was dependent upon metabolic labeling and click chemistry tagging, and TLC analysis suggested the possible formation of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate, the two most abundant phosphoinositide derivatives of PI

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