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As a result, the needles and drug content within the polymer matrix dissolve and remain in the body, while the backing layer can be removed after a few minutes, once the needles have been inserted into the skin and come into contact with body fluids

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Furthermore, growth factor-dependent pathways such as MAPK (extracellular signal-regulated kinases 1 and 2 [ERK 1/2]) and protein kinase B are found to be affected by GIP activation [20]