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The presence of peritumoral lymphatic vessels accelerates LN metastasis in patients with head and neck cancer by accelerating lymphatic intravasation (72) and actively promotes cancer cell transport to LNs in preclinical models via chemoinvasion that utilizes chemokine signaling pathway such as CCR7 CCL21 (87, 88), CXCR4 CXCL12 (89), and CCL1-CCR8 (90) ( Figure 1 )

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