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Prospective cohort studies on the association have been inconsistent: a few studies have linked higher choline intakes to increased risks of atrial fibrillation (122) and cardiovascular disease-related mortality (43, 44), while several other prospective studies have found no association between choline intake and cardiovascular disease endpoints (41, 45-48)

Available from: Hashimoto E, Tokushige K, Ludwig J

We have evidence that it is effective, although it has only been studied in this area of the body

First, the inclusion of 22 highly correlated genetic instruments with almost perfect LD violates the assumption of instrument variable analysis, which the instrument needs to be independent