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Setmelanotide AUC and Cmax increased proportionally following multiple-dose subcutaneous administration in the proposed dose range (1-3 mg)

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Subsequently, an analysis of pooled data from 20 clinical trials comprising over 9000 patients with T2DM confirmed that the drug was not associated with an increased risk for ischemic events [57]

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Severe or persistent abdominal pain, especially if radiating to the back and accompanied by nausea or vomiting, may indicate acute pancreatitisa serious adverse effect requiring emergency evaluation

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