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A study was considered relevant if it provided clinical, experimental, or epidemiological data related to one or more of the above domains

Small, temporary increases in resting heart rate have been observed in some participants during titration

Heise T, Mari A, DeVries JH et al (2022) Effects of subcutaneous tirzepatide versus placebo or semaglutide on pancreatic islet function and insulin sensitivity in adults with type 2 diabetes: a multicentre, randomised, double-blind, parallel-arm, phase 1 clinical trial

They also serve as a way to hold drug manufacturers accountable for their negligent actions and failure to prioritize patient safety