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These pullbacks are consistent with a national trend of public-payer programs reducing discretionary anti-obesity drug spending while preserving coverage for medical necessity indications

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cerevisiae , because it induces the expression of MET30 (Wu et al., 2009), which encodes an F-box protein of the SCF Met30 complex involved in the inactivation of the Met4 transcription factor that induces directly the expression of MET3, MET14 , and MET16 when the Met or SAM level is low (Rouillon et al., 2000)