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For semaglutide, elevated temperatures disrupt two types of molecular bonds that hold the peptide together: hydrogen bonds and hydrophobic interactions

If you've been following the medical weight loss conversation, you already know that injectable drugs like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) have fundamentally changed how medicine approaches obesity and metabolic health

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Rather than asking whether metformin should stay or go, clinicians should focus on how best to tailor therapy to individual patient needs