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In summary, the receptor-dependent and receptor-independent effects of melatonin in PC are as follows: Receptordependent effects of melatonin in PC: In PDAC models, melatonin in combination with sorafenib inhibits tumor growth by PDGFR-/STAT3 signaling blockade and melatonin receptor-mediated STAT3, and further increases mitochondrial dysfunction and apoptosis in tumor cells