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People with type 2 diabetes have an 84% higher baseline risk of developing pancreatitis compared to the general population

Direct engagement of those receptors may reduce inflammation in vascular tissue, improve endothelial function, and modulate the immune and metabolic processes that drive atherosclerotic plaque development and instability

Excessive tirzepatide exposure can cause severe nausea, vomiting, diarrhea, abdominal pain, acute pancreatitis, hypoglycemia, and rapid dehydration

The drug's primary action involves binding to both GIP and GLP-1 receptors, which are naturally occurring incretin hormones that regulate glucose metabolism and appetite