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flavescens extract (45 g/mL) specifically inhibited ASM contraction in tracheal rings of asthmatic mice [106]

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The logic behind this approach is that the concomitant activation of GLP1 and estrogen receptors may drive additional favorable effects, when compared with the individual activation of these pathways, which are known to conduct, on their own, beneficial metabolic actions on energy and glucose homeostasis 52

The efficacy of both combination therapies and individual herbal treatments has been extensively researched