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Peer-reviewed research supports its application in cognitive enhancement and neurodegenerative disease contexts

Bock-Marquette and co-workers reported in Nature (2004) that Tb4 promotes cardiomyocyte survival post-myocardial-infarction in mice through PINCH/ILK/Akt signaling, and Smart and colleagues showed in 2007 that the same peptide mobilizes adult epicardial progenitor cells

This makes supplements more similar to the natural kind of B12 in foods and a combination of methylcobalamin, adenosylcobalamin and hydroxocobalamin is considered ideal