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Comparison with Other COMT Inhibitors Drug Site of Action Liver Toxicity Notes Entacapone Peripheral only Low Most commonly used Tolcapone Peripheral + CNS High Requires liver monitoring Opicapone Peripheral Low Long-acting, once daily --- 11
[PubMed Citation] The efficacy of hydroxocobalamin (vitamin B12a) as a specific, nontoxic antidote in acute cyanide poisoning was tested
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We focus on the number of over-volunteering attempts detected by JACiCs Subject Matching System in healthy volunteers studies as data reflecting the reality of over-volunteering in Japan
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