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Diagnosing PA: the commonest non-nutritional cause of vitamin B deficiency Given how NICE guidelines are used in practice, we find that the guidelines lack specific advice on the clinical scenarios in which practitioners should suspect AIG and PA

(2023) Endocrine Reviews , 44(6): 10471073 (Harvard Medical School / University of Pennsylvania) Comprehensive review establishing NAD+ as a cofactor for sirtuins, PARPs, and CD38 enzymes, confirming age-related NAD+ decline as a driver of mitochondrial dysfunction and nuclear-mitochondrial communication breakdown

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