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the medication enhances, not replaces, these changes Genetics: Differences in receptor response mean some patients naturally respond better to one treatment than the other Starting weight: Higher BMI often leads to greater weight loss in kilograms, though percentage loss is similar Other medications: Certain drugs can reduce effectiveness by counteracting appetite suppression Difference Between Mounjaro and Wegovy: Side Effects Side effects are a key factor when choosing between Mounjaro and Wegovy, as tolerability affects adherence and outcomes Common side effects (both): Nausea Vomiting Diarrhoea Constipation Most noticeable during early dose escalation In the SURMOUNT-5 trial, Discontinuation due to side effects was lower with tirzepatide (2.7%) Individual response varies: Some patients tolerate Wegovy better Others find Mounjaro easier to manage No reliable way to predict tolerance in advance Important practical difference: Mounjaro may reduce the absorption of oral medications during dose increases This includes the combined oral contraceptive pill Additional contraceptive precautions are recommended for 4 weeks after each dose escalation Mounjaro vs Wegovy UK: Which Should You Choose