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Moreover, several investigators have found evidence of decreased activity of TPP-dependent enzymes, -ketoglutarate dehydrogenase and transketolase, in the brains of patients who died of AD (59)

This protein is secreted by neutrophils, monocytes/macrophages, and other cell types (such as epithelium) during pathogen infections, but it is also present in the intracellular milieu (Zhou et al., 2023)

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A patient on maximum-dose semaglutide (2.4 mg weekly) does not typically start tirzepatide at 15 mg