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The combination is a real dehydration risk, particularly for tirzepatide users where dehydration from GI side effects has been associated with kidney complications

doi: 10.1038/s41598-020-58838-2 226 de MeloISVDos SantosAFBuenoNB

GLP-12023212GLP-1GLP-1 GLP-1GLP-1GLP-1 GLP-1 GLP-1 -1Glucagonlikepeptide-1,GLP-1LincretinGLP-1GLP-1R GLP-1 -1(GLP-1RA) GLP-1 1.GLP-1GLP-1 2.GLP-1GLP-1 3.GLP-1GLP-1 4.GLP-1 GLP-1 1902BaylissStarlingsecretin 1906Moore 1930ZunzLaBarreincretinGLP-1 1985GLP-131GLP-12DPP-4GLP-1 1990Exendin-4(GLP-1RA)GLP-1GLP-1 2005Exendin-4GLP-1RAGLP-1GLP-1RA 2009Liraglutide2GLP-1RAGLP-1 2014GLP-1RAGLP-1 2017GLP-1RA220172021 2022GLP-1/GIPGLP-1/GIP220222023 GLP-1 2.2024GLP-1200 4.2024GLP-1 2024GLP-1- vip.pharnexcloud.com/?zmt-mhwz15

In this regard, PRODH may act in a manner analogous to other mitochondrial CoQ 10 oxidoreductases, helping to maintain the redox state of CoQ 10 under conditions of oxidative stress