In the SCALE Obesity and Prediabetes trial (Pi-Sunyer et al., NEJM 2015), participants receiving Saxenda alongside lifestyle modification achieved mean weight loss of approximately 8% of initial body weight, compared with 2.6% in the placebo group
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This is highly speculative because: Oral bioavailability differs between species Route of administration affects systemic exposure Species differences in peptide metabolism and clearance are unknown Current Practice Patterns Current practice patterns from unregulated sources typically involve: Subcutaneous injection: 0.25-0.5 mg once or twice daily, administered near injection sites for localized effects or abdominally for systemic distribution
