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Xu Q, et al
The first drug targeting the GLP-1 receptor was exenatide, released in 2005 as a twice-daily injection to treat type II diabetes
Abbreviations ACEI: angiotensin-converting enzyme inhibitors AHAs: anti-hyperglycemic agents Ang II: angiotensin II ARBs: angiotensin receptor blockers BP: blood pressure BUN: blood urea nitrogen CI: confidence interval CV: cardiovascular DKD: diabetic kidney disease DPP-4: dipeptidyl peptidase-4 eGFR: estimated glomerular filtration rate EGP: endogenous glucose production FPG: fasting plasma glucose GFR: glomerular filtration rate GLP-1: glucagon-like peptide-1 GLP1-RAs: glucagon-like peptide-1 receptor agonists HbA1c: glycated haemoglobin HDL-C: high density lipoprotein-cholesterol HF: heart failure HGP: hepatic glucose production LDL-C: low density lipoprotein-cholesterol MACE: major adverse cardiovascular events MRAs: mineralocorticoid receptor antagonists NF-kB: nuclear factor kappa B OLETF: Otsuka Long-Evans Tokushima Fatty PK-PD: pharmokinetics and pharmacodynamic RAAS: reninangiotensinaldosterone system RAS: reninangiotensin system RCT: randomized controlled trial SBP: systolic blood pressure SGLT2: sodiumglucose co-transporter 2 STZ: streptozocin T2DM: type 2 diabetes mellitus UACR: urine albumincreatinine ratio UGE: urinary glucose excretion References Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, et al
So what do you do when the clinical data doesnt give you the complete answer
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