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For brain region abbreviations please refer to cFos whole-brain imaging in the methods section

This fluorescence characteristic can be used for qualitative and quantitative analysis of peptides

[10] [22] Disease-modifying therapies commonly used in MS include: Injectable therapies : Interferon beta preparations (Avonex, Rebif, Betaseron) and glatiramer acetate (Copaxone) Oral agents : Fingolimod (Gilenya), dimethyl fumarate (Tecfidera), teriflunomide (Aubagio), siponimod (Mayzent), ozanimod (Zeposia), and cladribine (Mavenclad) Infusion therapies : Natalizumab (Tysabri), ocrelizumab (Ocrevus), alemtuzumab (Lemtrada) Subcutaneous injection : Ofatumumab (Kesimpta) No direct drug-drug interactions between tirzepatide and these DMTs have been identified in pharmacological studies