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If more than 5 days have passed, skip the missed dose and take the next dose on the next scheduled day according to your dosing schedule

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However, growing evidence indicates that alternative metabolic routes such as malic enzyme 1 (ME1), isocitrate dehydrogenases (IDH1 and IDH2), and the folate cycle also significantly contribute to NADPH production, particularly under stress conditions or during metabolic reprogramming [43]

This two-step pathway accounts for 80 to 90% of all alcohol clearance in low-to-moderate drinkers