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Cortisol affects neuronal mitochondrial function in a biphasic manner : Low, normal levels of cortisol increase mitochondrial function Chronically high levels of cortisol decrease mitochondrial function.[ref] Chronic stress alters cortisol levels and thus can affect mitochondrial function in the brain

Some practitioners recommend combining oral and injectable BPC-157 for comprehensive protocols for example, injecting near a tendon injury while simultaneously taking oral BPC-157 for gut support during a period of NSAID use

doi: 10.1111/APA.15870 166 StephensonTPinto PereiraSMRoz ShafranRde StavolaBLRojasNMcOwatKet al

"Effect of chronic ranitidine treatment on secretion of intrinsic factor"