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Phase 2 trials (NEJM, 2023) reported mean resting heart rate increases of approximately 57 bpm at doses of 8 mg and 12 mg weekly

Clinical Evidence 2026 Update: Phase 3 TRIUMPH Data In December 2025, Eli Lilly reported the first successful Phase 3 readout for retatrutide (LY3437943) from the TRIUMPH-4 trial

Retatrutide Dosing Current retatrutide dosing follows a gradual dose-escalation approach to improve tolerability and reduce gastrointestinal side effects

Another important finding of this study was that exenatide was also found to abolish the harmful effects of ritonavir (GLUT4 antagonist) on survival [52]