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464 Systemic and pulmonary hypertension are the main clinical causes of heart enlargement, cardiac fibrosis, and eventually heart failure

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More serious but less common side effects can include swelling in the hands or feet, increased blood sugar, allergic reactions, or numbness and tingling

APAP can produce ROS during liver injury, thereby inducing the activation of Nrf2 (Figure 3) (Reisman et al., 2009)