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"These results support the remarkable potential for people living with type 2 diabetes." In a 40-week Phase 3 randomized, double-blind, placebo-controlled trial for retatrutide, which included 537 participants, the drug showed average A1C reductions of up to 2% and participants lost an average of 36.6 pounds, or roughly 17% weight loss

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doi: 10.1038/nature11588 84 LupferCThomasPGAnandPKVogelPMilastaSMartinezJet al

Before it entered the mainstream, the best solution anyone had to the obesity epidemic was something along the lines of radical full-scale cultural upheaval