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GLP-1 drugs like semaglutide can slow gastric emptying and raise gastric pressure, and smaller, more frequent meals reduce stomach distension that can trigger hiccups

2 The findings from the OASIS 4 trial, published in the New England Journal of Medicine in September 2025, led the FDA to approve the Wegovy pill in December 2025, making it the first oral GLP-1 medication approved specifically for weight loss

More significant weight loss typically develops over three to six months as dosing is gradually increased

Saxenda, or liraglutide, is another GLP-1 receptor antagonist that increases feelings of fullness and suppresses appetite, leading to effective and successful weight loss