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Akkermansia muciniphila generates postbiotics propionate and P9, Clostridium butyricum produces butyrate, and Bifidobacterium infantis creates acetate and lactate that nourish other beneficial bacteria

Additionally, gene copy number variations (CNVs) such as tandem amplifications, deletions, and extrachromosomal circular or linear DNA contribute to genomic diversity (Black et al., 2023)

This difference is vital since the majority of clinical instances pertain to individuals with pre-existing fibrosis, necessitating curative rather than preventive measures

For instance, dysregulated sphingolipid metabolism, including elevated ceramide levels, can promote immune cell apoptosis, thus weakening the immune response