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NAD Contraindications & Potential Risks While NAD and its precursors ( NR, NMN, Niacin ) are generally considered safe, there are certain situations where caution is advised

Quite remarkably, in those with low POP levels, the typically robust association between diabetes and obesity was not observed in a nested case-controlled study, suggesting that obesity may exaggerate the metabolic disturbances caused by POPs (perhaps because adipose tissue provides a reservoir for fat-soluble toxins), rather than being directly responsible for the altered metabolism

Many studies have confirmed that abnormal mitophagy is a key factor in the occurrence and development of metabolic diseases, and targeted improvement of mitophagy abnormalities may become a new entry point for future prevention and treatment of metabolic diseases (Table 1)

3.2 Advantages, Limitations, and Applications of GO Analysis The primary advantage of Gene Ontology (GO) lies in its detailed granularity and standardized hierarchical structure, which enables precise functional interpretation across diverse biological systems