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The intestine is not only the central place for digestion and absorption but also the largest immune organ of the body, which can effectively prevent harmful substances such as external pathogens from invading the body The damage of the intestinal epithelial barrier increases intestinal permeability and leads to the invasion of the internal environment by adverse external factors (Pcha, 2000)

For obese individuals with T2DM a decrease in weight of 510% is clinically significant and is associated with improvements in cardiovascular risk factors ( Statements Author contributions MG and RP have contributed to the conception or design of the work, participated in the drafting of the manuscript and revising it critically for important intellectual content, approved the manuscript for publication and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved

e , Representative images of H&E staining of fetal liver cells from E12.5 Slc25a39 fl/fl and ErGFP-cre +/- Slc25a39 fl/fl embryos

Skin aging (reduced collagen, wrinkles): Fibroblasts lose repair capacity, leading to extracellular matrix degradation