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In line with this assumption, for all three viruses, we observed a highly significant enrichment of known physical interaction partners of the viral proteome among predicted tier-1 targets compared to tier-2 targets and all other enzymes (Fig

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OPG deficiency increases the number of M cells in gut-associated lymphoid tissue (GALT), enhances antibody responses to commensal bacteria, alleviates IBD, and reduces inflammation-induced abnormalities in bone metabolism (235)

These effects are the result of silymarin compounds being able to inhibit HCV RNA-dependent RNA polymerase activity (21)